Our research

Cannabinoid Isolation

Of the more than 100 known naturally-occurring cannabinoids, each studied to date demonstrates some sort of bioactivity. These cannabinoids, and their interactions with the complex and prevalent mammalian endocannabinoid system, form a long under-examined biological puzzle — one which hides a potential wealth of untapped chemical, medicinal, and neurological benefits.

Understanding this intricate relationship between cannabinoids and the endocannabinoid system — in particular its effect on the nervous systems of mammals — is the fundamental pillar of our research. By using medicinal chemistry as a means to tailor the natural pharmacophores of the cannabinoids, our structure-activity program looks to treat or cure a variety of medical conditions, while shedding light at long last on the functionality of the endocannabinoid system.

Cannabidiol

Cannabidiol (CBD) is naturally synthesized in C. sativa as CBDa via the enzymatic cyclization CBGa. It is naturally observed in most hemp strains anywhere from 1 to 20% by mass in dry hemp. With common hemp strains used in the United States and modern extraction methods, this quantity usually increases to between 30-50% by mass in unrefined extract. Though the CBDa is the original biological form of the molecule, the decarboxylated form of CBD is almost exclusively consumed. CBDa converts to CBD slowly over time and this conversion occurs nearly quantitatively when CBDa is exposed to temperatures above 120 °C.

Cannabigerol

Cannabigerol (CBG) is the biological precursor to CBD and THC. In C. sativa the biosynthesis of CBGa begins with the combination terpenoid phosphates, before enzymatically converting CBGa to THCa, CBDa, and CBCa. A mixture of CBG a and CBG are naturally observed in most hemp strains, though usually in quantities less than 1 % by mass in dry hemp. High CBG strains are known, but are not currently widely cultivated. With common hemp strains used in the United States and modern extraction methods, the quantity of CBGa usually increases to between 2-4% by mass in unrefined extract. This low abundance makes it difficult to separate and purify in large quantities. Like CBDa, CBGa converts to CBG slowly over time, and transformation that can occur rapidly with increased temperatures.

Cannabinol

Cannabinol (CBN) is the naturally occurring, non-enzymatic degradation product of THC. It is naturally observed in most hemp strains, though usually in quantities less than 1% by mass in dry hemp. With common hemp strains being used in the United States and current extraction methods, this quantity usually increases to between 1-2% by mass in an unrefined extract. This low abundance makes it difficult to separate and purify in large quantities.

Cannabichromene

Cannabichromene (CBC) is naturally synthesized in C. sativa as CBCa via the enzymatic cyclization of CBGa. CBCa and CBC is naturally observed in most hemp strains, though usually in quantities less than 1% by mass in dry hemp. With common hemp strains used in the United States and modern extraction methods, this quantity usually increases to between 2-4% by mass in unrefined extract. Isolation of large quantities of pure CBC shares the same difficulties as CBG and CBN. Additionally, the same decarboxylation process that occurs in other cannabinoids transforms CBCa to CBC.

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TREEHOUSE BIOTECH

Treehouse Biotech is pioneering scientific advances in the chemistry and biochemistry of cannabinoids. With more than 70 known naturally-occurring cannabinoids, we recognize the immense unexplored potential of this unique class of compounds. Our team of trained organic, analytical, and natural product chemists is able to provide unique and advanced solutions for research and development in the industrial hemp space.

These statements have not been evaluated by the Food and Drug Administration. These products are not intended to diagnose, treat, cure or prevent any disease.

© 2018 Treehouse Hemp

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